Chemotherapy may provide no benefit for breast cancer in some cases

Chemotherapy may provide no benefit for breast cancer in some cases

Chemotherapy may provide no benefit for breast cancer in some cases

Judy Perkins, a 49-year-old engineer from Florida, was selected to undergo the cutting edge treatment after several chemotherapy sessions had failed to kill the tumour, which had begun to spread to her liver. Mrs Perkins said she left her job and "was planning on dying".

"This is another significant step towards personalised breast cancer treatment and we hope these practice-changing findings will now help refine our use of chemotherapy on the NHS", she said. "The doctors were all excited". She's dedicated her life to helping women just like her.

Chosen for their ability to home in on four mutant proteins present in all of her cancer cells, the TILs broke down and carried off the two large tumors growing on her chest wall, along with four tennis-ball-sized tumors lodged in her liver. Otis Brawley, chief medical and scientific officer of the American Cancer Society, called the trial a good example of "precision medicine" and said it would save many women from unneeded chemotherapy. Many women think "if I don't get chemotherapy I'm going to die, and if I get chemo I'm going to be cured", but the results show there's a sliding scale of benefit and sometimes none, he said. All are examples of common cancers that don't typically respond to other immunotherapies.

They sequenced the DNA of Judy Perkins' tumor to find which mutations were unique to the cancer.

After the treatment, all of this patient's cancer disappeared and has not returned more than 22 months later.

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A breakthrough in breast cancer treatment reveals that there's no benefit from chemotherapy for 70 percent of women with the most common type of breast cancer.

"It's elegant in its simplicity", said Dr.

Breast cancer is the leading cause of cancer death in women worldwide, causing some 1.7 million new cases annually and over half a million deaths.

The trial is due to enrol around 330 patients to fully put the technique through its paces, and should be able to generate statistically-validated results in 2023. The treatments "weren't pleasant", she concedes.

"It's labor-intensive", she said. "This will significantly impact the way we approach things".

Almost 70 percent with common breast cancer could skip chemo, study says
The patients in this group were randomly assigned to chemotherapy with supplemental hormone therapy or just hormone therapy alone. The study was funded by the National Cancer Institute, some foundations and proceeds from the US breast cancer postage stamp.

Doctors all over the world are amazed by this development. Adjuvant chemotherapy guided by a 21-gene expression assay in breast cancer [published online June 3, 2018]. The Foster City, Calif., company is building out a pipeline of cancer drugs after years of success with treating viral infections such as hepatitis and HIV.

Still, he acknowledged that most patients with this form of advanced cancer will die within months, and "we need to do a lot more work".

Albain said research is ongoing, as scientists are now exploring questions about what types of chemotherapy might be effective on various groups based on their genomics, and what will happen to the participants of the clinical trial as even more time passes. The fortified immune warriors are then expanded and reinfused into the patient.

So-called "immunotherapy" has already been shown to work in some people with cancer of the lung, cervix, blood cells (leukaemia), skin (melanoma) and bladder. Two CAR-T immunotherapy treatments have been approved for use by the Food and Drug Administration - Kymriah and Yescarta - but more are in the pipeline.

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