'London patient': second case ever of HIV remission

'London patient': second case ever of HIV remission

'London patient': second case ever of HIV remission

Gupta added that the method used is not appropriate for all patients but offers hope for new treatment strategies, including gene therapies. Treatment for HIV involves medications that suppress the virus, known as antiretroviral therapy, which people with HIV need to take for their entire lives.

His case is similar to the first man cured of HIV in 2007. To do this in others, exact match donors would have to be found in the tiny proportion of people-most of them of northern European descent-who have the CCR5 mutation that makes them resistant to the virus.

"Coming 10 years after the successful report of the Berlin Patient, this new case confirms that bone marrow transplantation from a CCR5-negative donor can eliminate residual virus and stop any traces of virus from rebounding". "I never thought that there would be a cure during my lifetime".

This is obviously mind-blowing news, but there's a caveat: most experts agree that it can't be a solution for many HIV patients. However, because HIV remained undetectable, he is still considered clinically cured of his infection, according to his doctors.

The "London patient" told the paper that it was "surreal" and "overwhelming" to learn that he could be cured of H.I.V. and cancer. Almost one million people die every year from HIV-related causes.

The London man was cured after he received a bone marrow transplant from an HIV-resistant donor, his doctors said.

'London Patient' Appears to Become the Second Person Ever Cured of AIDS
After chemotherapy, he underwent a stem cell transplant in 2016 and subsequently remained on antiretroviral therapy for 16 months. This is obviously mind-blowing news, but there's a caveat: most experts agree that it can't be a solution for many HIV patients.

Although the patient has been in remission for 18 months, the authors of the British study published Tuesday in the science journal Nature cautioned it was too early to say he had been cured.

The patient voluntarily stopped taking HIV drugs to see if the virus would come back.

Timothy Ray Brown, 52, formerly referred to as the "Berlin patient", also underwent a bone-marrow transplant to treat his Leukemia.

In 2016, when he was very sick with cancer, doctors chose to seek a transplant match for him.

The London patient has answered that question: A near-death experience is not required for the procedure to work.

Despite various attempts by scientists using the same approach, Brown had remained the only person cured of HIV until the new London patient.

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Gupta, now at Cambridge University, treated the London patient when he was working at University College London. He was diagnosed with HIV in 2003 and started taking drugs to control the infection in 2012. The donor - who was unrelated - had a rare genetic mutation known as "CCR5 delta 32", that resists HIV infection.

The scientists are describing the case as a long-term remission publically, while most experts are calling it a cure, the paper reported.

"In a way, the only person to compare with directly is the Berlin patient", he said.

"I'm not sure what this tells us", said Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases.

"Even if we're not going to cure the world with stem cell transplants", Johnston says, "it's important to have a collection of people who've been cured so we can put together that information to figure out how we can do a cure more broadly".

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